Regulation of the Matrix Microenvironment for Stem Cell Engineering and Regenerative Medicine

被引：40

作者：

Huang, Ngan F. ^{[2
]}

Li, Song ^{[1
]}

机构：

[1] Univ Calif Berkeley, Dept Bioengn, Berkeley, CA 94720 USA

[2] Stanford Univ, Div Cardiovasc Med, Stanford, CA 94305 USA

来源：

ANNALS OF BIOMEDICAL ENGINEERING | 2011年 / 39卷 / 04期

基金：

美国国家卫生研究院;

关键词：

Stem cells; Extracellular matrix; Mechanotransduction; Nanopatterning; Micropatterning; Spatial patterning; Matrix rigidity; Vascular graft; SMOOTH-MUSCLE-CELLS; EXTRACELLULAR-MATRIX; GROWTH-FACTOR; ELECTRICAL BEHAVIOR; SENSITIVE HYDROGELS; GENE DELIVERY; SELF-RENEWAL; IN-VIVO; SCAFFOLD; DIFFERENTIATION;

D O I：

10.1007/s10439-011-0297-2

中图分类号：

R318 [生物医学工程];

学科分类号：

100103 [病原生物学];

摘要：

The extracellular matrix (ECM) microenvironment consists of structural and functional molecules. The ECM relays both biochemical and biophysical cues to and from the cells to modulate cell behavior and function. The biophysical cues can be engineered and applied to cells by means of spatial patterning, matrix rigidity, and matrix actuation. Tissue engineering strategies that utilize ECMs to direct stem cell organization and lineage specification show tremendous potential. This review describes the technologies for modulating ECM spatial patterning, matrix rigidity, chemical composition, and matrix actuation. The role of ECMs in vascular tissue engineering is then discussed as a model of tissue engineering and regenerative medicine.

引用

页码：1201 / 1214

页数：14

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