Hepatitis C Virus: Assembly and Release of Virus Particles

被引：87

作者：

Jones, Daniel M. ^{[1
]}

McLauchlan, John ^{[1
]}

机构：

[1] MRC, Virol Unit, Glasgow G11 5JR, Lanark, Scotland

来源：

JOURNAL OF BIOLOGICAL CHEMISTRY | 2010年 / 285卷 / 30期

基金：

英国医学研究理事会;

关键词：

NONSTRUCTURAL PROTEIN 5A; SIGNAL PEPTIDE PEPTIDASE; CORE PROTEIN; LIPID DROPLET; LOW-DENSITY; RNA REPLICATION; COMPENSATORY MUTATIONS; NONTRANSLATED REGION; TRANS-ENCAPSIDATION; CELL TRANSMISSION;

D O I：

10.1074/jbc.R110.133017

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Hepatitis C virus is a blood-borne virus that typically establishes a chronic infection in the liver, which often results in cirrhosis and hepatocellular carcinoma. Progress in understanding the complete virus life cycle has been greatly enhanced by the recent availability of a tissue culture system that produces infectious virus progeny. Thus, it is now possible to gain insight into the roles played by viral components in assembly and egress and the cellular pathways that contribute to virion formation. This minireview describes the key determining viral and host factors that are needed to produce infectious virus.

引用

收藏

页码：22732 / 22738

页数：7

相关论文

共 86 条

[71] The hepatitis C virus RNA 3′-untranslated region strongly enhances translation directed by the internal ribosome entry site [J].

Song, Yutong ;

Friebe, Peter ;

Tzima, Eleni ;

Juenemann, Christiane ;

Bartenschlager, Ralf ;

Niepmann, Michael .

JOURNAL OF VIROLOGY, 2006, 80 (23) :11579-11588

[72] Efficient trans-encapsidation of hepatitis C virus RNAs into infectious virus-like particles [J].

Steinmann, Eike ;

Brohm, Christiane ;

Kallis, Stephanie ;

Bartenschlager, Ralf ;

Pietschmann, Thomas .

JOURNAL OF VIROLOGY, 2008, 82 (14) :7034-7046

[73] Hepatitis C virus p7 protein is crucial for assembly and release of infectious virions [J].

Steinmann, Eike ;

Penin, Francois ;

Kallis, Stephanie ;

Patel, Arvind H. ;

Bartenschlager, Ralf ;

Pietschmann, Thomas .

PLOS PATHOGENS, 2007, 3 (07) :962-971

[74] Inhibition of hepatitis C virus p7 membrane channels in a liposome-based assay system [J].

StGelais, Corine ;

Tuthill, Tobias J. ;

Clarke, Dean S. ;

Rowlands, David J. ;

Harris, Mark ;

Griffin, Stephen .

ANTIVIRAL RESEARCH, 2007, 76 (01) :48-58

[75] Visualization of double-stranded RNA in cells supporting hepatitis C virus RNA replication [J].

Targett-Adams, Paul ;

Boulant, Steeve ;

McLauchlan, John .

JOURNAL OF VIROLOGY, 2008, 82 (05) :2182-2195

[76] Maturation of hepatitis C virus core protein by signal peptide peptidase is required for virus production [J].

Targett-Adams, Paul ;

Hope, Graham ;

Boulant, Steeve ;

McLauchlan, John .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2008, 283 (24) :16850-16859

[77] SnapShot: The ESCRT Machinery [J].

Teis, David ;

Saksena, Suraj ;

Emr, Scott D. .

CELL, 2009, 137 (01)

[78] Regulation of hepatitis C virion production via phosphorylation of the NS5A protein [J].

Tellinghuisen, Timothy L. ;

Foss, Katie L. .

PLOS PATHOGENS, 2008, 4 (03)

[79] Identification of residues required for RNA replication in domains II and III of the hepatitis C virus NS5A protein [J].

Tellinghuisen, Timothy L. ;

Foss, Katie L. ;

Treadaway, Jason C. ;

Rice, Charles M. .

JOURNAL OF VIROLOGY, 2008, 82 (03) :1073-1083

[80] Structure of the zinc-binding domain of an essential component of the hepatitis C virus replicase [J].

Tellinghuisen, TL ;

Marcotrigiano, J ;

Rice, CM .

NATURE, 2005, 435 (7040) :374-379

← 1 2 3 4 5 6 7 8 9 →