Effects of lactoferrin, soya germ and polyamine on 2-amino-1-methyl-6-phenylimidazo[4,5-b]-pyridine(PhIP)-induced breast carcinogenesis in rats

被引：8

作者：

Haba, R ^{[1
]}

Watanabe, S ^{[1
]}

Wada, M ^{[1
]}

Udaka, S ^{[1
]}

机构：

[1] Tokyo Univ Agr, Fac Appl Biosci, Setagaya Ku, Tokyo 1568502, Japan

来源：

BIOFACTORS | 2004年 / 22卷 / 1-4期

关键词：

Lactoferrin; isoflavone; polyamine; cancer prevention; mammary carcinogenesis;

D O I：

10.1002/biof.5520220125

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The cancer-preventive effects of food-derived bovine lactoferrin(bLF), isoflavone-rich soya germ(SG), and spermidine(SPD) on mammary gland carcinogenesis induced by 2-amino-1-methyl-6-pheiiyliniidazo[4,5-b]-pyridine (PhIP), were investigated in female Sprague-Dawley(SD) rats. Two hundred and six female SD rats were divided into 8 groups. Cumulative breast cancer incidence at 43 weeks was 65.4% in the PhIP group; 80.0% and 76.0% in the 0.2% and 2.0% bLF groups, respectively: 58.3% and 20.0% in the 2% and 10% SG groups, respectively; and 80.0% and 76.9% in the 0.035% and 0.175% SPD groups, respectively. Isoflavone-rich SG significantly suppressed breast cancer, and the tumors showed fibrous or less malignant features upon histological examination.

引用

页码：127 / 131

页数：5

共 5 条

[1]

ADLERCREUTZ CHT, 1995, J NUTR, V125, P757

[2] INDUCTION OF MAMMARY-TUMORS IN FEMALE SPRAGUE-DAWLEY RATS BY THE FOOD-DERIVED CARCINOGEN 2-AMINO-1-METHYL-6-PHENYLIMIDAZO[4,5-B]PYRIDINE AND EFFECT OF DIETARY-FAT [J].

GHOSHAL, A ;

PREISEGGER, KH ;

TAKAYAMA, S ;

THORGEIRSSON, SS ;

SNYDERWINE, EG .

CARCINOGENESIS, 1994, 15 (11) :2429-2433

[3]

Haba Ryota, 2002, Environ Health Prev Med, V7, P64, DOI 10.1007/BF02897332

[4] FACTORS AFFECTING ISOFLAVONE CONTENT IN SOYBEAN SEEDS - CHANGES IN ISOFLAVONES, SAPONINS, AND COMPOSITION OF FATTY-ACIDS AT DIFFERENT TEMPERATURES DURING SEED DEVELOPMENT [J].

TSUKAMOTO, C ;

SHIMADA, S ;

IGITA, K ;

KUDOU, S ;

KOKUBUN, M ;

OKUBO, K ;

KITAMURA, K .

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 1995, 43 (05) :1184-1192

[5] Possible chemopreventive effects of bovine lactoferrin on esophagus and lung carcinogenesis in the rat [J].

Ushida, Y ;

Sekine, K ;

Kuhara, T ;

Takasuka, N ;

Iigo, M ;

Maeda, M ;

Tsuda, H .

JAPANESE JOURNAL OF CANCER RESEARCH, 1999, 90 (03) :262-267

← 1 →