Incidence and prognostic value of TET2 alterations in de novo acute myeloid leukemia achieving complete remission

被引：107

作者：

Nibourel, Olivier ^{[1
,2
,3
,4
]}

Kosmider, Olivier ^{[5
,6
,7
]}

Cheok, Meyling ^{[2
,3
,4
]}

Boissel, Nicolas ^{[8
]}

Renneville, Aline ^{[1
,2
,3
,4
]}

Philippe, Nathalie ^{[1
]}

Dombret, Herve ^{[8
]}

Dreyfus, Francois ^{[9
]}

Quesnel, Bruno ^{[2
,3
,4
,10
]}

Geffroy, Sandrine ^{[1
]}

Quentin, Samuel ^{[11
]}

Roche-Lestienne, Catherine ^{[1
,2
,3
,4
]}

Cayuela, Jean-Michel ^{[11
]}

Roumier, Christophe ^{[1
,2
,3
,4
]}

Fenaux, Pierre ^{[12
]}

Vainchenker, William ^{[13
]}

Bernard, Olivier A. ^{[14
]}

Soulier, Jean ^{[11
]}

Fontenay, Michaela ^{[5
,6
,7
]}

Preudhomme, Claude ^{[1
,2
,3
,4
]}

机构：

[1] CHRU, Hematol Lab, F-59037 Lille, France

[2] INSERM, U837, F-59045 Lille, France

[3] Univ Lille Nord France, Lille, France

[4] Inst Rech Canc Lille, Lille, France

[5] CNRS, INSERM, U567, UMR 8104, Paris, France

[6] Inst Cochin, Paris, France

[7] Univ Paris 05, AP HP, Hop Cochin, Hematol Lab, Paris, France

[8] Univ Paris 07, AP HP, Hop St Louis, Serv Hematol Adulte, Paris, France

[9] Univ Paris 05, AP HP, Hop Cochin, Serv Hematol Clin, Paris, France

[10] CHU Lille, Serv Malad Sang, F-59037 Lille, France

[11] Univ Paris 07, Hop St Louis, Inst Univ Hematol, INSERM,U944,Lab Cent Hematol,AP HP, Paris, France

[12] Univ Paris 13, AP HP, Hop Avicenne, Serv Hematol, Bobigny, France

[13] Univ Paris 11, Inst Gustave Roussy, U790, INSERM, Villejuif, France

[14] Univ Paris 05, INSERM, Eo210, Hop Necker,Fac Med, Paris, France

来源：

BLOOD | 2010年 / 116卷 / 07期

关键词：

MUTATIONS;

D O I：

10.1182/blood-2009-07-234484

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Mutations of the ten eleven translocation 2 gene (TET2) have recently been reported in myelodysplastic syndrome and myeloproliferative neoplasms. We analyzed the incidence and prognostic value of TET2 point mutations and other genomic alterations by direct sequencing and single nucleotide polymorphism microarray analysis in 111 de novo acute myeloid leukemia, who had all achieved complete remission (CR). Mutations were observed in 19 (17%) of the 111 patients compared with 10 (27%) of 36 patients who had failed to achieve CR (P = .2). In the 111 patients who had achieved CR, TET2 alterations were only significantly associated with NPM1 mutations but not with other pretreatment characteristics. TET2 gene status was not significantly correlated with disease-free survival and overall survival, both in the entire cohort and in patients with normal karyotype. (Blood. 2010;116(7):1132-1135)

引用

页码：1132 / 1135

页数：4

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