Phosphatidylinositol transfer proteins: the long and winding road to physiological function

被引：77

作者：

Kearns, BG ^{[1
]}

Alb, JG ^{[1
]}

Bankaitis, VA ^{[1
]}

机构：

[1] Univ Alabama Birmingham, Dept Cell Biol, Birmingham, AL 35294 USA

来源：

TRENDS IN CELL BIOLOGY | 1998年 / 8卷 / 07期

关键词：

D O I：

10.1016/S0962-8924(98)01281-1

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Phosphatidylinositol transfer proteins (PITPs) have historically been thought to help execute lipid-sorting events by transporting phospholipid monomers between membrane bilayers. Recent data, however, indicate unanticipated roles for PITPs in the coordination and/or coupling of phospholipid metabolism with vesicle trafficking and the downregulation of signal-transduction reactions. We are only now beginning to appreciate both the identities of PITP-dependent cellular reactions and the intriguing mechanisms by which PITPs execute their functions in eukaryotic cells.

引用

页码：276 / 282

页数：7

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