A short and efficient total synthesis of the naturally occurring coumarins siderin, kotanin, isokotanin A and desertorin C

被引：21

作者：

Hüttel, W

Nieger, M

Müller, M

机构：

[1] Forschungszentrum Julich, Inst Biotechnol 2, D-52425 Julich, Germany

[2] Univ Bonn, Inst Anorgan Chem, D-53121 Bonn, Germany

来源：

SYNTHESIS-STUTTGART | 2003年 / 12期

关键词：

atropisomerism; biaryls; oxidative phenolic coupling; natural coumarins;

D O I：

10.1055/s-2003-41027

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Starting from methyl 2-hydroxy-4-methoxy-6-methylbenzoate (6) and its regioisomeric dehydrodimers 7-9, readily available by an oxidative coupling reaction of 6, the naturally occurring coumarins siderin (1), kotanin (2), isokotanin A (3) and desertorin C (4) were synthesized in a novel and highly efficient three-step transformation. In the case of kotanin (2) both atropisomers were prepared from the pure atropisomers of 7.

引用

页码：1803 / 1808

页数：6

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