Mass spectrometry based methods for analysis of nucleosides as antiviral drugs and potential tumor biomarkers

被引：13

作者：

Agrofoglio, Luigi A. ^{[1
]}

Bezy, Vincent ^{[1
]}

Chaimbault, Patrick ^{[1
]}

Delepee, Raphaeel ^{[1
]}

Rhourri, Boutaina ^{[1
]}

Morin, Philippe ^{[1
]}

机构：

[1] Univ Orleans, CNRS, Inst Chim Organ & Analyt, UMR 6005, F-45067 Orleans, France

来源：

NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS | 2007年 / 26卷 / 10-12期

关键词：

antiviral; HIV; nucleosides; LC-MS/MS; therapeutic drug monitoring;

D O I：

10.1080/15257770701544336

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The intracellular analysis of the phosphorylated metabolites of some anti-HIV nucleosides by liquid chromatography or capillary electrophoresis coupled with tandem mass spectrometry (LC-MS/MS or CE-MS/MS) has been realized on human peripheral blood mononuclear cells (PBMC), with limit of quantitation (LOQ) that allow them to be quantitated intracellularly. We described also the analysis of modified urinary nucleosides as Potential tumor biomarkers.

引用

页码：1523 / 1527

页数：5

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