Identification of cross-talk between m6A and 5mC regulators associated with onco-immunogenic features and prognosis across 33 cancer types

被引：70

作者：

Chen, Yu-Tong ^{[1
,2
]}

Shen, Jia-Yi ^{[1
,3
]}

Chen, Dong-Ping ^{[1
,4
]}

Wu, Chen-Fei ^{[1
]}

Guo, Rui ^{[1
]}

Zhang, Pan-Pan ^{[1
]}

Lv, Jia-Wei ^{[1
]}

Li, Wen-Fei ^{[1
]}

Wang, Zi-Xian ^{[1
]}

Chen, Yu-Pei ^{[1
]}

机构：

[1] Sun Yat Sen Univ, State Key Lab Oncol South China, Guangdong Key Lab Nasopharyngeal Carcinoma Diag &, Collaborat Innovat Ctr Canc Med,Canc Ctr, Guangzhou 510060, Peoples R China

[2] Sun Yat Sen Univ, Affiliated Hosp 3, Dept Med Oncol, Guangzhou 510632, Peoples R China

[3] Jinan Univ, Sch Med, Guangzhou 510632, Peoples R China

[4] Sun Yat Sen Univ, Sch Life Sci, MOE Key Lab Gene Funct & Regulat, Guangzhou 510275, Peoples R China

来源：

JOURNAL OF HEMATOLOGY & ONCOLOGY | 2020年 / 13卷 / 01期

基金：

中国国家自然科学基金;

关键词：

m(6)A regulators; 5mC regulators; Pan-cancer analyses; Genomic alterations; Tumor microenvironment; Survival; DNA METHYLATION;

D O I：

10.1186/s13045-020-00854-w

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Methylation of RNA and DNA, notably in the forms of N6-methyladenosine (m(6)A) and 5-methylcytosine (5mC) respectively, plays crucial roles in diverse biological processes. Currently, there is a lack of knowledge regarding the cross-talk between m(6)A and 5mC regulators. Thus, we systematically performed a pan-cancer genomic analysis by depicting the molecular correlations between m(6)A and 5mC regulators across 11,000 subjects representing 33 cancer types. For the first time, we identified cross-talk between m(6)A and 5mC methylation at the multiomic level. Then, we further established m(6)A/5mC epigenetic module eigengenes by combining hub m(6)A/5mC regulators and informed a comprehensive epigenetic state. The model reflected status of the tumor-immune-stromal microenvironment and was able to predict patient survival in the majority of cancer types. Our results lay a solid foundation for epigenetic regulation in human cancer and pave a new road for related therapeutic targets.

引用

页数：5

共 8 条

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