HPV16/18 L1 VLP vaccine induces cross-neutralizing antibodies that may mediate cross-protection

被引：118

作者：

Kemp, Troy J. ^{[1
]}

Hildesheim, Allan ^{[2
]}

Safaeian, Mahboobeh ^{[2
]}

Dauner, Joseph G. ^{[1
]}

Pan, Yuanji ^{[1
]}

Porras, Carolina ^{[3
]}

Schiller, John T. ^{[4
]}

Lowy, Douglas R. ^{[4
]}

Herrero, Rolando ^{[3
]}

Pinto, Ligia A. ^{[1
]}

机构：

[1] NCI Frederick, HPV Immunol Lab, SAIC Frederick Inc, Frederick, MD 21702 USA

[2] NCI, Div Canc Epidemiol & Genet, NIH, Bethesda, MD 20892 USA

[3] Fdn INCIENSA, Proyecto Epidemiol Guanacaste, San Jose, Costa Rica

[4] NCI, Cellular Oncol Lab, Ctr Canc Res, NIH, Bethesda, MD 20892 USA

来源：

VACCINE | 2011年 / 29卷 / 11期

基金：

美国国家卫生研究院;

关键词：

Human papillomavirus; Antibody; Vaccine; PARTICLE VACCINE; YOUNG-WOMEN; INFECTION; EFFICACY; IMMUNIZATION; RESPONSES; TYPE-18; HPV-18;

D O I：

10.1016/j.vaccine.2011.01.001

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Human papillomavirus (HPV) L1 VLP-based vaccines are protective against HPV vaccine-related types; however, the correlates of protection have not been defined. We observed that vaccination with Cervarix (TM) induced cross-neutralizing antibodies for HPV types for which evidence of vaccine efficacy has been demonstrated (HPV31/45) but not for other types (HPV52/58). In addition, HPV31/45 cross-neutralizing titers showed a significant increase with number of doses (HPV31, p < 0.001; HPV45, p < 0.001) and correlated with HPV16/18 neutralizing titers, respectively. These findings raise the possibility that cross-neutralizing antibodies are effectors of cross-protection observed for the HPV16/18 vaccine.(C) 2011 Elsevier Ltd. All rights reserved.

引用

页码：2011 / 2014

页数：4

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