Histone Lysine Demethylase JARID1a Activates CLOCK-BMAL1 and Influences the Circadian Clock

被引：188

作者：

DiTacchio, Luciano ^{[1
]}

Le, Hiep D. ^{[1
]}

Vollmers, Christopher ^{[1
]}

Hatori, Megumi ^{[1
]}

Witcher, Michael ^{[2
]}

Secombe, Julie ^{[3
]}

Panda, Satchidananda ^{[1
]}

机构：

[1] Salk Inst Biol Studies, Regulatory Biol Lab, La Jolla, CA 92037 USA

[2] McGill Univ, Dept Oncol, Montreal, PQ H2W 1S6, Canada

[3] Albert Einstein Coll Med, Dept Genet, Bronx, NY 10461 USA

来源：

SCIENCE | 2011年 / 333卷 / 6051期

基金：

日本学术振兴会;

关键词：

DISTINCT;

D O I：

10.1126/science.1206022

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

070301 [无机化学]; 070403 [天体物理学]; 070507 [自然资源与国土空间规划学]; 090105 [作物生产系统与生态工程];

摘要：

In animals, circadian oscillators are based on a transcription-translation circuit that revolves around the transcription factors CLOCK and BMAL1. We found that the JumonjiC (JmjC) and ARID domain-containing histone lysine demethylase 1a (JARID1a) formed a complex with CLOCK-BMAL1, which was recruited to the Per2 promoter. JARID1a increased histone acetylation by inhibiting histone deacetylase 1 function and enhanced transcription by CLOCK-BMAL1 in a demethylase-independent manner. Depletion of JARID1a in mammalian cells reduced Per promoter histone acetylation, dampened expression of canonical circadian genes, and shortened the period of circadian rhythms. Drosophila lines with reduced expression of the Jarid1a homolog, lid, had lowered Per expression and similarly altered circadian rhythms. JARID1a thus has a nonredundant role in circadian oscillator function.

引用

页码：1881 / 1885

页数：5

共 9 条

[1]

Circadian regulator CLOCK is a histone acetyltransferase [J].