Elevated substance p levels in HIV-infected men

被引：56

作者：

Douglas, SD ^{[1
]}

Ho, WZ

Gettes, DR

Cnaan, A

Zhao, HQ

Leserman, J

Petitto, JM

Golden, RN

Evans, DL

机构：

[1] Childrens Hosp Philadelphia, Div Infect Dis & Immunol, Immunol Sect, Joseph Stokes Jr Res Inst, Philadelphia, PA 19104 USA

[2] Univ Penn, Sch Med, Dept Pediat, Philadelphia, PA 19104 USA

[3] Univ Penn, Sch Med, Dept Psychiat, Philadelphia, PA 19104 USA

[4] Univ N Carolina, Chapel Hill, NC USA

[5] Univ Florida, Gainesville, FL USA

来源：

AIDS | 2001年 / 15卷 / 15期

关键词：

D O I：

10.1097/00002030-200110190-00019

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The neuropeptide, substance P, is a potent modulator of neuroimmunoregulation. Substance P and its receptor modulate HIV infection. HIV-seropositive men had significantly higher plasma substance P levels compared with uninfected controls, which were associated with decreased CD16 and CD56 natural killer (NK) cell populations. The changes in plasma substance P levels and decreases in NK subsets did not correlate with CD4 cell levels, but a diurnal pattern was suggested for substance P. The balance between substance P expression and functions of immune cells may be important in the immunopathogenesis of HIV infection.

引用

页码：2043 / 2045

页数：3

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