HCC-1, a novel chemokine from human plasma

被引:114
作者
SchulzKnappe, P
Magert, HJ
Dewald, B
Meyer, M
Cetin, Y
Kubbies, M
Tomeczkowski, J
Kirchhoff, K
Raida, M
Adermann, K
Kist, A
Reinecke, M
Sillard, R
Pardigol, A
Uguccioni, M
Baggiolini, M
Forssmann, WG
机构
[1] LOWER SAXONY INST PEPTIDE RES,D-30625 HANNOVER,GERMANY
[2] UNIV BERN,THEODOR KOCHER INST,CH-3012 BERN,SWITZERLAND
[3] SCH MED,DEPT ANAT,D-30625 HANNOVER,GERMANY
[4] BOEHRINGER MANNHEIM GMBH,D-82377 PENZBERG,GERMANY
[5] SCH MED,DEPT PEDIAT HEMATOL & ONCOL,D-30625 HANNOVER,GERMANY
[6] UNIV ZURICH,DEPT ANAT,CH-8057 ZURICH,SWITZERLAND
关键词
D O I
10.1084/jem.183.1.295
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
A novel CC chemokine, HCC-1, was isolated from the hemofiltrate of patients with chronic renal failure. HCC-1 has a relative molecular mass of 8,673 and consists of 71 amino acids including four cysteines linked to disulfide bonds. HCC-1 cDNA was cloned from human bone marrow and shown to code for the mature protein plus a putative 19-residue leader sequence. Mature HCC-1 has sequence identity of 46% with macrophage inflammatory protein (MIP)-1 alpha and MIP-1 beta, and 29-37% with the other human CC chemokines. Unlike MIP-1 alpha and the other CC chemokines, HCC-1 is expressed constitutively in several normal tissues (spleen, liver, skeletal and heart muscle, gut, and bone marrow), and is present at high concentrations (1-80 nM) in plasma. HCC-1 has weak activities on human monocytes and acts via receptors that also recognize MIP-1 alpha. It induced intracellular Ca2+ changes and enzyme release, but no chemotaxis, at concentrations of 100-1,000 nM, and was inactive on T lymphocytes, neutrophils, and eosinophil leukocytes. In addition, HCC-1 enhanced the proliferation of CD34(+) myeloid progenitor cells. It was as effective as MIP-1 alpha, but about 100-fold less potent.
引用
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页码:295 / 299
页数:5
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