Enantioselective dehydrohalogenation using chiral alkoxides: Design of a catalytic system allowing access to axially dissymmetric compounds

被引:14
作者
Amadji, M [1 ]
Vadecard, J [1 ]
Cahard, D [1 ]
Duhamel, L [1 ]
Duhamel, P [1 ]
Plaquevent, JC [1 ]
机构
[1] Univ Rouen, Fac Sci, IRCOF, UPRES A CNRS 6014,Lab Fonct Azotees & Oxygenees C, F-76821 Mont St Aignan, France
关键词
D O I
10.1021/jo9806456
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
The use of chiral alkoxides obtained from ephedrines for enantioselective proton abstraction is described in full. These reagents allow the practical obtention of axially dissymmetric 1,3-dioxanes via highly enantioselective dehydrohalogenation reactions. The conditions for a catalytic use of these chiral alkoxides are defined.
引用
收藏
页码:5541 / 5546
页数:6
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