Rehabilitating the addicted brain with transcranial magnetic stimulation

被引：191

作者：

Diana, Marco ^{[1
]}

Raij, Tommi ^{[2
,3
]}

Melis, Miriam ^{[4
]}

Nummenmaa, Aapo ^{[5
]}

Leggio, Lorenzo ^{[6
,7
,8
]}

Bonci, Antonello ^{[9
,10
,11
]}

机构：

[1] Univ Sassari, Dept Chem & Pharm, G Minardi Lab Cognit Neurosci, I-07100 Sassari, Italy

[2] Northwestern Univ, Shirley Ryan AbilityLab, Ctr Brain Stimulat, Dept Phys Med & Rehabil, Chicago, IL 60611 USA

[3] Northwestern Univ, Dept Neurobiol, Chicago, IL 60611 USA

[4] Univ Cagliari, Div Neurosci & Clin Pharmacol, Dept Biomed Sci, I-09042 Monserrato, Italy

[5] Harvard Med Sch, Massachusetts Gen Hosp, MIT, HMS,Athinoula A Martinos Ctr Biomed Imaging, Boston, MA 02129 USA

[6] US Natl Inst Alcohol Abuse & Alcoholism, Sect Clin Psychoneuroendocrinol & Neuropsychophar, Div Intramural Clin & Biol Res NIAAA DICBR, Bethesda, MD 20892 USA

[7] US Natl Inst Drug Abuse, Intramural Res Program NIDA IRP, NIH, Bethesda, MD 20892 USA

[8] Brown Univ, Ctr Alcohol & Addict Studies, Providence, RI 02912 USA

[9] US Natl Inst Drug Abuse, Intramural Res Program NIDA IRP, Baltimore, MD 21224 USA

[10] Johns Hopkins Univ, Dept Neurosci, Baltimore, MD 21224 USA

[11] Johns Hopkins Univ, Dept Psychiat, Baltimore, MD 21224 USA

来源：

NATURE REVIEWS NEUROSCIENCE | 2017年 / 18卷 / 11期

关键词：

HUMAN MOTOR CORTEX; THETA-BURST-STIMULATION; LONG-TERM DEPRESSION; DORSOLATERAL PREFRONTAL CORTEX; PAIRED-PULSE STIMULATION; VENTRAL TEGMENTAL AREA; HUMAN CEREBRAL-CORTEX; ELECTRIC-FIELD; CORTICAL EXCITABILITY; SYNAPTIC PLASTICITY;

D O I：

10.1038/nrn.2017.113

中图分类号：

Q189 [神经科学];

学科分类号：

071006 [神经生物学];

摘要：

Substance use disorders (SUDs) are one of the leading causes of morbidity and mortality worldwide. In spite of considerable advances in understanding the neural underpinnings of SUDs, therapeutic options remain limited. Recent studies have highlighted the potential of transcranial magnetic stimulation (TMS) as an innovative, safe and cost-effective treatment for some SUDs. Repetitive TMS (rTMS) influences neural activity in the short and long term by mechanisms involving neuroplasticity both locally, under the stimulating coil, and at the network level, throughout the brain. The long-term neurophysiological changes induced by rTMS have the potential to affect behaviours relating to drug craving, intake and relapse. Here, we review TMS mechanisms and evidence that rTMS is opening new avenues in addiction treatments.

引用

页码：685 / 693

页数：9

共 180 条

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