Fluoxetine increases the content of neurotrophic protein S100β in the rat hippocampus

被引：73

作者：

Manev, R ^{[1
]}

Uz, T ^{[1
]}

Manev, H ^{[1
]}

机构：

[1] Univ Illinois, Dept Psychiat, Inst Psychiat, Chicago, IL 60612 USA

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 2001年 / 420卷 / 2-3期

关键词：

neurogenesis; antidepressant; glia;

D O I：

10.1016/S0014-2999(01)00989-X

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Recent studies indicate that a protracted daily administration of the antidepressant fluoxetine to adult rats increases cell proliferation/neurogenesis in the hippocampus. It has been hypothesized that this action of fluoxetine might be mediated by neurotrophic factors. We hypothesized that glial S100 beta could be such a factor, and using quantitative Western immunoblotting. we investigated the effect of a 21-day treatment of rats with fluoxetine (5 mg/kg). and found that fluoxetine increases the content of hippocampal S 100 beta. (C) 2001 Elsevier Science B.V. All rights reserved.

引用

页码：R1 / R2

页数：2

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