Post-transcriptional control of the interferon system

被引：66

作者：

Khabar, Khalid S. A.

Young, Howard A.

机构：

[1] King Faisal Specialist Hosp & Res Ctr, Program BioMol Res, Riyadh 11211, Saudi Arabia

[2] Natl Canc Inst, Canc Res Ctr, Expt Immunol Lab, Ft Detrick, MD 21702 USA

来源：

BIOCHIMIE | 2007年 / 89卷 / 6-7期

关键词：

interferons; post-transcriptional; 3 ' untranslated regions; mRNA stability; AU-rich elements;

D O I：

10.1016/j.biochi.2007.02.008

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The interferon (IFN) system is a well-controlled network of signaling, transcriptional, and post-transcriptional processes that orchestrate host defense against microbes. The IFN response comprises a multi-array of IFN-stimulated gene products that mediate a variety of biological processes designed to control infection and regulate specific immune responses. In this review, we focus on post-transcriptional mechanisms of gene regulation that occur during the course of IFN induction and during the response of cells to IFN. Post-transcriptional mechanisms involve different levels of regulation such as mRNA stability, alternative splicing, and translation. Such controls offer a fine tuning mechanism for efficient and rapid response and as a negative feedback control in IFN biosynthesis and response. (C) 2007 Elsevier Masson SAS. All rights reserved.

引用

页码：761 / 769

页数：9

共 88 条

[1] TYPE-I INTERFERONS (IFN-ALPHA AND IFN-BETA) SUPPRESS CYTOTOXIN (TUMOR-NECROSIS-FACTOR-ALPHA AND LYMPHOTOXIN)PRODUCTION BY MITOGEN-STIMULATED HUMAN PERIPHERAL-BLOOD MONONUCLEAR-CELLS [J].