Regulation of adipogenesis and energy balance by PPARγ and PGC-1

被引：85

作者：

Spiegelman, BM

Puigserver, P

Wu, Z

机构：

[1] Dana Farber Canc Inst, Div Cellular & Mol Biol, Boston, MA 02115 USA

[2] Harvard Univ, Sch Med, Boston, MA USA

来源：

INTERNATIONAL JOURNAL OF OBESITY | 2000年 / 24卷 / Suppl 4期

关键词：

PPAR gamma; adipogenesis; fat cells; energy balance;

D O I：

10.1038/sj.ijo.0801492

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

There has been a great deal of recent progress in our understanding of the transcriptional control of adipogenesis. Current data suggest that fat cell differentiation involves an interplay between the C/EBP family of transcription factors and PPAR gamma, The thermogenic program of brown fat cells may also include a contribution from a new coactivator, PGC-1. Recent data suggests that this cosactivator is responsible for activation of thermogenesis and oxidative metabolism in both brown fat and muscle. The PGC-1 dependent program includes both mitochondrial biogenesis and tissue-specific expression of uncoupling proteins.

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收藏

页码：S8 / S10

页数：3

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