Vacuole-creating protein in neurodegenerative diseases in humans

被引：75

作者：

Mizuno, Y

Hori, S

Kakizuka, A

Okamoto, K

机构：

[1] Gunma Univ, Grad Sch Med, Dept Neurol, Maebashi, Gumma 3718511, Japan

[2] Kyoto Univ, Grad Sch Biostudies, Kyoto 6068501, Japan

来源：

NEUROSCIENCE LETTERS | 2003年 / 343卷 / 02期

关键词：

vacuole-creating protein; AAA family; ubiquitin; Alzheimer's disease; motor neuron disease; dementia; Parkinson's disease;

D O I：

10.1016/S0304-3940(03)00280-5

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Vacuole-creating protein (VCP) is a member of the ATPases associated with diverse cellular activities and is a putative sensor protein for degenerative proteins. Immunohistochemical examinations demonstrated that VCP was observed in ubiquitin-positive intraneuronal inclusions in motor neuron disease with dementia, ballooned neurons in Creutzfeldt-Jakob disease, dystrophic neurites of senile plaque in Alzheimer's disease, and Lewy and Marinesco bodies and Lewy neurites in Parkinson's disease, while granules of granulovacuolar degeneration and neurofibrillary tangles in Alzheimer's disease were not positively stained for VCP. These results indicate that VCP reacts with abnormal or misfolded proteins and plays a role in accelerating the process of degeneration and cell death. The elucidation of an association between VCP and these degenerative proteins will provide an important clue for understanding common mechanisms underlying neurodegenerative diseases. (C) 2003 Elsevier Science Ireland Ltd. All rights reserved.

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页码：77 / 80

页数：4

相关论文

共 17 条

[1] VCP/p97 in abnormal protein aggregates, cytoplasmic vacuoles, and cell death, phenotypes relevant to neurodegeneration [J].

Hirabayashi, M ;

Inoue, K ;

Tanaka, K ;

Nakadate, K ;

Ohsawa, Y ;

Kamei, Y ;

Popiel, AH ;

Sinohara, A ;

Iwamatsu, A ;

Kimura, Y ;

Uchiyama, Y ;

Hori, S ;

Kakizuka, A .

CELL DEATH AND DIFFERENTIATION, 2001, 8 (10) :977-984

[2] Protein precipitation: a common etiology in neurodegenerative disorders? [J].

Kakizuka, A .

TRENDS IN GENETICS, 1998, 14 (10) :396-402

[3] ALZ-50, UBIQUITIN AND TAU-IMMUNOREACTIVITY OF NEUROFIBRILLARY TANGLES, PICK BODIES AND LEWY BODIES [J].

LOVE, S ;

SAITOH, T ;

QUIJADA, S ;

COLE, GM ;

TERRY, RD .

JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY, 1988, 47 (04) :393-405

[4] UBIQUITIN IS A COMMON FACTOR IN INTERMEDIATE FILAMENT INCLUSION-BODIES OF DIVERSE TYPE IN MAN, INCLUDING THOSE OF PARKINSONS-DISEASE, PICKS DISEASE, AND ALZHEIMERS-DISEASE, AS WELL AS ROSENTHAL FIBERS IN CEREBELLAR ASTROCYTOMAS, CYTOPLASMIC BODIES IN MUSCLE, AND MALLORY BODIES IN ALCOHOLIC LIVER-DISEASE [J].

LOWE, J ;

BLANCHARD, A ;

MORRELL, K ;

LENNOX, G ;

REYNOLDS, L ;

BILLETT, M ;

LANDON, M ;

MAYER, RJ .

JOURNAL OF PATHOLOGY, 1988, 155 (01) :9-15

[5] A FILAMENTOUS INCLUSION BODY WITHIN ANTERIOR HORN NEURONS IN MOTOR NEURON DISEASE DEFINED BY IMMUNOCYTOCHEMICAL LOCALIZATION OF UBIQUITIN [J].

LOWE, J ;

LENNOX, G ;

JEFFERSON, D ;

MORRELL, K ;

MCQUIRE, D ;

GRAY, T ;

LANDON, M ;

DOHERTY, FJ ;

MAYER, RJ .

NEUROSCIENCE LETTERS, 1988, 94 (1-2) :203-210

[6] INCLUSION-BODIES IN MOTOR CORTEX AND BRAIN-STEM OF PATIENTS WITH MOTOR NEURON DISEASE ARE DETECTED BY IMMUNOCYTOCHEMICAL LOCALIZATION OF UBIQUITIN [J].

LOWE, J ;

ALDRIDGE, F ;

LENNOX, G ;

DOHERTY, F ;

JEFFERSON, D ;

LANDON, M ;

MAYER, RJ .

NEUROSCIENCE LETTERS, 1989, 105 (1-2) :7-13

[7] The mouse p97 (CDC48) gene -: Genomic structure, definition of transcriptional regulatory sequences, gene expression, and characterization of a pseudogene [J].

Müller, JMM ;

Meyer, HH ;

Ruhrberg, C ;

Stamp, GW ;

Warren, G ;

Shima, DT .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (15) :10154-10162

[8] REEXAMINATION OF GRANULOVACUOLAR DEGENERATION [J].

OKAMOTO, K ;

HIRAI, S ;

IIZUKA, T ;

YANAGISAWA, T ;

WATANABE, M .

ACTA NEUROPATHOLOGICA, 1991, 82 (05) :340-345

[9] Electron micrograph of ubiquitin-positive intraneuronal inclusions in the extra-motor cortices in patients with amyotrophic lateral sclerosis [J].

Okamoto, K ;

Hirai, S ;

Amari, M ;

Sakurai, A .

NEUROPATHOLOGY, 1996, 16 (02) :112-116

[10] NEW UBIQUITIN-POSITIVE INTRANEURONAL INCLUSIONS IN THE EXTRA-MOTOR CORTICES IN PATIENTS WITH AMYOTROPHIC-LATERAL-SCLEROSIS [J].

OKAMOTO, K ;

HIRAI, S ;

YAMAZAKI, T ;

SUN, XY ;

NAKAZATO, Y .

NEUROSCIENCE LETTERS, 1991, 129 (02) :233-236