Parallel kinetic resolution of 4-alkynals catalyzed by Rh(I)/Tol-BINAP: Synthesis of enantioenriched cyclobutanones and cyclopentenones

被引：135

作者：

Tanaka, K ^{[1
]}

Fu, GC ^{[1
]}

机构：

[1] MIT, Dept Chem, Cambridge, MA 02139 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2003年 / 125卷 / 27期

关键词：

D O I：

10.1021/ja035489l

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A Rh(I)/(R)-Tol-BINAP catalyst reacts with a racemic mixture of 4-alkynals to selectively furnish a cyclobutanone from the (R)-substrate and a cyclopentenone from the (S)-substrate. This method is noteworthy from several standpoints, including the scarcity of parallel kinetic resolutions (especially those that are catalyzed or that involve carbon-carbon bond formation) and the dearth of catalytic processes that generate enantioenriched cyclobutanones. Copyright © 2003 American Chemical Society.

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页码：8078 / 8079

页数：2

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