Randomized study of chemotherapy and surgery versus radiotherapy for stage IIIA non-small-cell lung cancer: a National Cancer Institute of Canada Clinical Trials Group Study

被引：55

作者：

Shepherd, FA

Johnston, MR

Payne, D

Burkes, R

Deslauriers, J

Cormier, Y

de Bedoya, LD

Ottaway, J

James, K

Zee, B

机构：

[1] Univ Toronto, Interdept Div Oncol, Toronto, ON, Canada

[2] Hop Laval, St Foy, PQ, Canada

[3] Univ Laval, St Foy, PQ G1K 7P4, Canada

[4] Natl Canc Inst, Canada Clin Trials Grp, Kingston, ON, Canada

[5] Queens Univ, Kingston, ON, Canada

来源：

BRITISH JOURNAL OF CANCER | 1998年 / 78卷 / 05期

关键词：

induction chemotherapy; combined-modality therapy; non-small-cell lung cancer;

D O I：

10.1038/bjc.1998.560

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Thirty-one patients with stage IIIA (N2) non-small-cell lung cancer were randomized to receive radiotherapy alone or chemotherapy with cisplatin and vinblastine followed by surgery. Response rates to induction chemotherapy and radiotherapy were 50% and 53.3% respectively. Complete surgical resection was possible for 62.5% of patients. Median survival times were 16.2 and 18.7 months for radiotherapy alone and chemotherapy-surgery respectively (P = Ns), with no long-term improvement in survival seen with combined-modality treatment.

引用

页码：683 / 685

页数：3

共 8 条

[1] INDUCTION THERAPY FOLLOWED BY DEFINITIVE LOCAL-CONTROL FOR STAGE-III NON-SMALL-CELL LUNG-CANCER - A REVIEW, WITH A FOCUS ON RECENT TRIMODALITY TRIALS [J].