Vasoactive intestinal peptide regulates Th17 function in autoimmune inflammation

被引:38
作者
Leceta, Javier [1 ]
Gomariz, Rosa P.
Martinez, Carmen
Carrion, Mar
Arranz, Alicia
Juarranz, Yasmina
机构
[1] Univ Complutense, Fac Biol, Dept Cell Biol, ES-28040 Madrid, Spain
[2] Univ Complutense, Fac Med, Dept Cell Biol, Madrid, Spain
关键词
vasoactive intestinal peptide; T regulatory cells; Th17; autoimmunity;
D O I
10.1159/000110636
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
An imbalance of pro-inflammatory and anti-inflammatory cytokines, autoreactive and inflammatory T helper 1 (Th1) cells, and regulatory T (Treg) cells results in the loss of immune tolerance and the subsequent appearance of inflammatory autoimmune diseases. On the other hand, hormones and neuropeptides are endogenous factors controlling the immune homeostasis that have been proposed as therapeutic agents in different autoimmune disorders. Among them, the vasoactive intestinal peptide (VIP) has been shown to downregulate the inflammatory response and to alter the Th1/Th2 balance in favor of anti-inflammatory Th2 immune responses. Recent studies have revealed a greater diversification of the T cell effector repertoire with the identification of Th17 cells. This subpopulation has been shown to be pathogenic in several autoimmune diseases previously attributed to the Th1 lineage. Arising new data and a critical revision of already published studies indicate that VIP is an immunomodulatory therapeutic agent targeting the Th17/Treg pathway. Copyright (C) 2007 S. Karger AG, Basel.
引用
收藏
页码:134 / 138
页数:5
相关论文
共 30 条
[1]   CDNA array analysis of cytokines, chemokines, and receptors involved in the development of TNBS-induced colitis:: Homeostatic role of VIP [J].
Abad, C ;
Juarranz, Y ;
Martinez, C ;
Arranz, A ;
Rosignoli, F ;
García-Gómez, M ;
Leceta, J ;
Gomariz, RP .
INFLAMMATORY BOWEL DISEASES, 2005, 11 (07) :674-684
[2]   Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells [J].
Bettelli, E ;
Carrier, YJ ;
Gao, WD ;
Korn, T ;
Strom, TB ;
Oukka, M ;
Weiner, HL ;
Kuchroo, VK .
NATURE, 2006, 441 (7090) :235-238
[3]   Novel IL-12 family members shed light on the orchestration of Th1 responses [J].
Brombacher, F ;
Kastelein, RA ;
Alber, G .
TRENDS IN IMMUNOLOGY, 2003, 24 (04) :207-212
[4]   CD25brightCD4+ regulatory T cells are enriched in inflamed joints of patients with chronic rheumatic disease [J].
Cao, DJ ;
van Vollenhoven, R ;
Klareskog, L ;
Trollmo, C ;
Malmström, V .
ARTHRITIS RESEARCH & THERAPY, 2004, 6 (04) :R335-R346
[5]   Conversion of peripheral CD4+CD25- naive T cells to CD4+CD25+ regulatory T cells by TGF-β induction of transcription factor Foxp3 [J].
Chen, WJ ;
Jin, WW ;
Hardegen, N ;
Lei, KJ ;
Li, L ;
Marinos, N ;
McGrady, G ;
Wahl, SM .
JOURNAL OF EXPERIMENTAL MEDICINE, 2003, 198 (12) :1875-1886
[6]   Vasoactive intestinal peptide induces regulatory dendritic cells with therapeutic effects on autoimmune disorders [J].
Chorny, A ;
Gonzalez-Rey, E ;
Fernandez-Martin, A ;
Pozo, D ;
Ganea, D ;
Delgado, M .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2005, 102 (38) :13562-13567
[7]   Chemokine receptors in inflammation: an overview [J].
D'Ambrosio, D ;
Panina-Bordignon, P ;
Sinigaglia, F .
JOURNAL OF IMMUNOLOGICAL METHODS, 2003, 273 (1-2) :3-13
[8]   Vasoactive intestinal peptide generates CD4+ CD25+ regulatory T cells in vivo [J].
Delgado, M ;
Chorny, A ;
Gonzalez-Rey, E ;
Ganea, D .
JOURNAL OF LEUKOCYTE BIOLOGY, 2005, 78 (06) :1327-1338
[9]   VIP and PACAP inhibit IL-12 production in LPS-stimulated macrophages.: Subsequent effect on IFNγ synthesis by T cells [J].
Delgado, M ;
Munoz-Elias, EJ ;
Gomariz, RP ;
Ganea, D .
JOURNAL OF NEUROIMMUNOLOGY, 1999, 96 (02) :167-181
[10]   Vasoactive intestinal peptide in the immune system: potential therapeutic role in inflammatory and autoimmune diseases [J].
Delgado, M ;
Abad, C ;
Martinez, C ;
Juarranz, MG ;
Arranz, A ;
Gomariz, RP ;
Leceta, J .
JOURNAL OF MOLECULAR MEDICINE-JMM, 2002, 80 (01) :16-24