Serum levels of osteocalcin are inversely associated with the metabolic syndrome and the severity of coronary artery disease in Chinese men

被引:74
作者
Bao, Yuqian [1 ]
Zhou, Mi [1 ,2 ]
Lu, Zhigang [3 ]
Li, Huating [1 ,2 ]
Wang, Ye [1 ,2 ]
Sun, Leiqing [3 ]
Gao, Meifang [3 ]
Wei, Meng [3 ]
Jia, Weiping [1 ]
机构
[1] Shanghai Jiao Tong Univ, Affiliated Peoples Hosp 6, Dept Endocrinol & Metab,Shanghai Clin Ctr Diabet, Shanghai Diabet Inst,Shanghai Key Lab Diabet Mell, Shanghai 200233, Peoples R China
[2] Shanghai Jiao Tong Univ, Sch Med, Dept Med, Shanghai 200233, Peoples R China
[3] Shanghai Jiao Tong Univ, Affiliated Peoples Hosp 6, Dept Cardiol, Shanghai 200233, Peoples R China
关键词
BETA-CELL FUNCTION; INSULIN-RESISTANCE; PLASMA-GLUCOSE; DENSITY; ATHEROSCLEROSIS; EXPRESSION; PROTEINS; MARKERS;
D O I
10.1111/j.1365-2265.2011.04065.x
中图分类号
R5 [内科学];
学科分类号
100201 [内科学];
摘要
Objective Osteocalcin is a bone-derived protein and has been shown to play an important role in regulating glucose and fat metabolism. We therefore investigated the association of serum levels of osteocalcin with the metabolic syndrome (MS) and coronary atherosclerosis in Chinese men. Research design and methods Serum osteocalcin levels were measured by an electrochemiluminescence immunoassay in 181 men who underwent coronary angiography, and their association with the MS and the severity of coronary artery disease (CAD) were studied. Results Osteocalcin levels in patients with the MS were significantly lower compared with those in non-MS subjects (P < 0.001) and decreased correspondingly with the increasing number of components of the MS (P < 0.001). Multiple logistic regression analysis demonstrated that osteocalcin was independently associated with the MS (OR = 0.060, 95% CI: 0.005-0.651). In multiple stepwise regression analysis, waist circumference (P = 0.001) and fasting plasma glucose (P = 0.002) were independently associated with serum osteocalcin. Subgroup analysis in 60 subjects with normal glucose tolerance showed that serum osteocalcin decreased significantly in patients with CAD compared with those without CAD (P = 0.029) and decreased significantly as the number of stenotic vessels increased (P = 0.033). Furthermore, serum osteocalcin showed an independent correlation with coronary atherosclerosis index (standardized beta = -0.497, P = 0.003). Conclusion Serum osteocalcin is inversely associated with the MS as well as the severity of coronary atherosclerosis in Chinese men, supporting the new concept that bone has the reciprocal regulation with energy metabolism.
引用
收藏
页码:196 / 201
页数:6
相关论文
共 23 条
[1]
Anonymous, 2007, Zhonghua Xinxueguanbing Zazhi, V35, P390
[2]
Differential expression of bone matrix regulatory proteins in human atherosclerotic plaques [J].
Dhore, CR ;
Cleutjens, JPM ;
Lutgens, E ;
Cleutjens, KBJM ;
Geusens, PPM ;
Kitslaar, PJEHM ;
Tordoir, JHM ;
Spronk, HMH ;
Vermeer, C ;
Daemen, MJAP .
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2001, 21 (12) :1998-2003
[3]
SERUM AND URINARY MARKERS OF BONE REMODELING - ASSESSMENT OF BONE TURNOVER [J].
EPSTEIN, S .
ENDOCRINE REVIEWS, 1988, 9 (04) :437-449
[4]
Osteocalcin differentially regulates β cell and adipocyte gene expression and affects the development of metabolic diseases in wild-type mice [J].
Ferron, Mathieu ;
Hinoi, Eiichi ;
Karsenty, Gerard ;
Ducy, Patricia .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2008, 105 (13) :5266-5270
[5]
Diagnosis and management of the metabolic syndrome - An American Heart Association/National Heart, Lung, and Blood Institute Scientific Statement [J].
Grundy, SM ;
Cleeman, JI ;
Daniels, SR ;
Donato, KA ;
Eckel, RH ;
Franklin, BA ;
Gordon, DJ ;
Krauss, RM ;
Savage, PJ ;
Smith, SC ;
Spertus, JA ;
Costa, F .
CIRCULATION, 2005, 112 (17) :2735-2752
[6]
OSTEOCALCIN AND MATRIX GLA PROTEIN - VITAMIN K-DEPENDENT PROTEINS IN BONE [J].
HAUSCHKA, PV ;
LIAN, JB ;
COLE, DEC ;
GUNDBERG, CM .
PHYSIOLOGICAL REVIEWS, 1989, 69 (03) :990-1047
[7]
The uncarboxylated form of osteocalcin is associated with improved glucose tolerance and enhanced β-cell function in middle-aged male subjects [J].
Hwang, You-Cheol ;
Jeong, In-Kyung ;
Ahn, Kyu Jeung ;
Chung, Ho Yeon .
DIABETES-METABOLISM RESEARCH AND REVIEWS, 2009, 25 (08) :768-772
[8]
Relationship between osteocalcin and glucose metabolism in postmenopausal women [J].
Im, Jee-Aee ;
Yu, Byung-Pal ;
Jeon, Justin Y. ;
Kim, Sang-Hwan .
CLINICA CHIMICA ACTA, 2008, 396 (1-2) :66-69
[9]
JUDKINS MP, 1968, RADIOL CLIN N AM, V6, P467
[10]
Serum undercarboxylated osteocalcin was inversely associated with plasma glucose level and fat mass in type 2 diabetes mellitus [J].
Kanazawa, I. ;
Yamaguchi, T. ;
Yamauchi, M. ;
Yamamoto, M. ;
Kurioka, S. ;
Yano, S. ;
Sugimoto, T. .
OSTEOPOROSIS INTERNATIONAL, 2011, 22 (01) :187-194