Mild chemo-enzymatic synthesis of polymer-supported cinchona alkaloids and their application in asymmetric Michael addition

被引：25

作者：

Athawale, V ^{[1
]}

Manjrekar, N ^{[1
]}

机构：

[1] Univ Bombay, Dept Chem, Bombay 400098, Maharashtra, India

来源：

TETRAHEDRON LETTERS | 2001年 / 42卷 / 27期

关键词：

chemo-enzymatic synthesis; lipase; cinchona alkaloid; polymer-supported catalyst;

D O I：

10.1016/S0040-4039(01)00731-6

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Cinchona alkaloid (CA) monomers were synthesised enzymatically in high yield (90%) by selectively acrylating the primary -OH group of the CA, and the co-polymers obtained with acrylonitrile were tested for their efficiency for asymmetric induction in Michael addition reactions. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：4541 / 4543

页数：3

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