Effects of Early Life Stress on Neuroendocrine and Neurobehavior: Mechanisms and Implications

被引：55

作者：

Lai, Ming-Chi ^{[1
]}

Huang, Li-Tung ^{[2
]}

机构：

[1] Chi Mei Med Ctr, Dept Pediat, Tainan, Taiwan

[2] Chang Gung Univ, Coll Med, Kaohsiung Med Ctr, Chang Gung Mem Hosp,Dept Pediat, Kaohsiung, Taiwan

来源：

PEDIATRICS AND NEONATOLOGY | 2011年 / 52卷 / 03期

关键词：

early life stress; epileptogenesis; hypothalamic-pituitary-adrenal axis; learning and memory; psychiatric disorders; CORTICOTROPIN-RELEASING-FACTOR; PITUITARY-ADRENAL AXIS; MESSENGER-RNA EXPRESSION; EARLY POSTNATAL STRESS; ANXIETY-LIKE BEHAVIOR; RAT-BRAIN REGIONS; MATERNAL-DEPRIVATION; LONG-TERM; NEONATAL ISOLATION; SYNAPTIC PLASTICITY;

D O I：

10.1016/j.pedneo.2011.03.008

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Evidence continues to mount that adverse experiences early in life have an impact on brain functions. Early life stress can program the development of the hypothalamic-pituitary-adrenal axis and cause alterations of neurochemistry and signaling pathways involved in regulating neuroplasticity, with resultant neurobehavioral changes. Early life experiences and genetic factors appear to interact in determining the individual vulnerability to mental health disorders. We reviewed the effects of early life stress on neuroendocrine regulation and the relevance to neurobehavioral development. Copyright (C) 2011, Taiwan Pediatric Association. Published by Elsevier Taiwan LLC. All rights reserved.

引用

页码：122 / 129

页数：8

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