Pilot trial of 1-octanol in essential tremor

被引：53

作者：

Bushara, KO

Goldstein, SR

Grimes, GJ

Burstein, AH

Hallett, M

机构：

[1] Minneapolis Vet Affairs Med Ctr, Serv Neurol, Minneapolis, MN 55417 USA

[2] NINDS, Human Motor Control Sect, Med Neurol Branch, NIH, Bethesda, MD 20892 USA

[3] NIH, Warren G Magnuson Clin Ctr, Dept Pharm, Bethesda, MD 20892 USA

来源：

NEUROLOGY | 2004年 / 62卷 / 01期

关键词：

D O I：

10.1212/01.WNL.0000101722.95137.19

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

1-Octanol (an 8-C alcohol currently used as a food-flavoring agent) is known to inhibit tremor in essential tremor (ET) animal models at a much lower dose than ethyl alcohol. The authors conducted a randomized, placebo-controlled pilot trial of a single oral dose of 1 mg/kg of 1-octanol in 12 patients with ET. No significant side effects or signs of intoxication were observed. 1-Octanol significantly decreased tremor amplitude for up to 90 minutes. The results suggest 1-octanol as a well-tolerated and safe potential treatment for ET. Further trials are warranted.

引用

页码：122 / 124

页数：3

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