Gram-positive commensal bacteria for mucosal vaccine delivery

被引：42

作者：

Fischetti, VA ^{[1
]}

Medaglini, D ^{[1
]}

Pozzi, G ^{[1
]}

机构：

[1] UNIV SIENA, DEPT MOL BIOL, MICROBIOL SECT, I-53100 SIENA, ITALY

来源：

CURRENT OPINION IN BIOTECHNOLOGY | 1996年 / 7卷 / 06期

关键词：

D O I：

10.1016/S0958-1669(96)80079-6

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

To avoid the use of engineered pathogens for vaccine delivery, systems have been developed that allow the expression of heterologous antigens in commensal Gram-positive bacteria. In some cases, both a serum IgG and secretory IgA response are induced to the recombinant protein after vaccination, verifying the validity of the approach. These live recombinant bacteria may be used in the future to introduce a protective immune response to pathogenic microorganisms after mucosal colonization. (C) Current Biology Ltd ISSN 0958-1669.

引用

页码：659 / 666

页数：8

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