Transcriptional regulation of macrophage polarization: enabling diversity with identity

被引：1755

作者：

Lawrence, Toby ^{[1
]}

Natoli, Gioacchino ^{[2
]}

机构：

[1] Ctr Immunol Marseille Luminy, F-13288 Marseille, France

[2] European Inst Oncol, Dept Expt Oncol, I-20139 Milan, Italy

来源：

NATURE REVIEWS IMMUNOLOGY | 2011年 / 11卷 / 11期

基金：

欧洲研究理事会;

关键词：

ACTIVATED RECEPTOR-GAMMA; GENE-EXPRESSION; ALTERNATIVE ACTIVATION; METHYLTRANSFERASE COMPLEX; INFLAMMATORY MONOCYTES; TARGETED DISRUPTION; NEGATIVE REGULATOR; BINDING PROTEIN; M2; MACROPHAGES; KAPPA-B;

D O I：

10.1038/nri3088

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

In terms of both phenotype and function, macrophages have remarkable heterogeneity, which reflects the specialization of tissue-resident macrophages in microenvironments as different as liver, brain and bone. Also, marked changes in the activity and gene expression programmes of macrophages can occur when they come into contact with invading microorganisms or injured tissues. Therefore, the macrophage lineage includes a remarkable diversity of cells with different functions and functional states that are specified by a complex interplay between microenvironmental signals and a hardwired differentiation programme that determines macrophage identity. In this Review, we summarize the current knowledge of transcriptional and chromatin-mediated control of macrophage polarization in physiology and disease.

引用

页码：750 / 761

页数：12

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