The genetics of vertebrate myogenesis

被引:203
作者
Bryson-Richardson, Robert J. [1 ,2 ]
Currie, Peter D. [1 ,3 ]
机构
[1] Victor Chang Cardiac Res Inst, Sydney, NSW 2010, Australia
[2] Univ New S Wales, Fac Med, Sch Med Sci, Sydney, NSW 2052, Australia
[3] Univ New S Wales, St Vincents Hosp, Fac Med, St Vincents Clin Sch, Darlinghurst, NSW 2010, Australia
关键词
D O I
10.1038/nrg2369
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
The molecular, genetic and cellular bases for skeletal muscle growth and regeneration have been recently documented in a number of vertebrate species. These studies highlight the role of transient subcompartments of the early somite as a source of distinct waves of myogenic precursors. Individual myogenic progenitor populations undergo a complex series of cell rearrangements and specification events in different regions of the body, all of which are controlled by distinct gene regulatory networks. Collectively, these studies have opened a window into the morphogenetic and molecular bases of the different phases of vertebrate myogenesis, from embryo to adult.
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收藏
页码:632 / 646
页数:15
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