Vascular endothelial growth factor-C expression in human prostatic carcinoma and its relationship to lymph node metastasis

被引:247
作者
Tsurusaki, T
Kanda, S
Sakai, H
Kanetake, H
Saito, Y
Alitalo, K
Koji, T
机构
[1] Nagasaki Univ, Sch Med, Dept Urol, Nagasaki 8528102, Japan
[2] Nagasaki Univ, Sch Med, Dept Histol & Cell Biol, Nagasaki 8528102, Japan
[3] Univ Helsinki, Haartman Inst, Mol Canc Biol Lab, Helsinki 00014, Finland
关键词
prostatic carcinoma; vascular endothelial growth factor-C; VEGF receptor-3; lymph node metastasis;
D O I
10.1038/sj.bjc.6690356
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Lymph node dissemination is a major prognostic factor in human cancer. However, the molecular mechanisms underlying lymph node metastasis are poorly understood. Recently, Vascular endothelial growth factor-C (VEGF-C) was identified as a ligand for VEGF receptor-3 (VEGFR-3/Flt-4) and the expression of VEGFR-3 was found to be highly restricted to the lymphatic endothelial cells. In this report, we investigated the expression of VEGF-C and VEGFR-3 in human prostatic carcinoma tissue by using in situ hybridization and immunohistochemical staining respectively. Expression of VEGF-C mRNA in prostatic carcinoma was significantly higher in lymph node-positive group than in lymph node-negative group. In addition, the number of VEGFR-3-positive vessels was increased in stroma surrounding VEGF-C-positive prostatic carcinoma cells. These results suggest that the expression of VEGF-C in prostatic carcinoma cells is implicated in the lymph node metastasis.
引用
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页码:309 / 313
页数:5
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