The US Environmental Protection Agency particulate matter health effects research centers program:: A midcourse report of status, progress, and plans

被引:89
作者
Lippmann, M
Frampton, M
Schwartz, J
Dockery, D
Schlesinger, R
Koutrakis, P
Froines, J
Nel, A
Finkelstein, J
Godleski, J
Kaufman, J
Koenig, J
Larson, T
Luchtel, D
Liu, LJS
Oberdörster, G
Peters, A
Sarnat, J
Sioutas, C
Suh, H
Sullivan, J
Utell, M
Wichmann, E
Zelikoff, J
机构
[1] Univ Rochester, Sch Med & Dent, Rochester, NY USA
[2] Harvard Univ, Sch Publ Hlth, Boston, MA 02115 USA
[3] Univ Calif Los Angeles, Sch Publ Hlth, Los Angeles, CA 90024 USA
[4] Univ Calif Los Angeles, Sch Med, Los Angeles, CA USA
[5] Univ Washington, Sch Publ Hlth, Seattle, WA 98195 USA
[6] Univ So Calif, Los Angeles, CA USA
关键词
acute effects; biological mechanisms; chronic effects; criteria pollutants; dosimetry; exposure assessment; infrastructure; morbidity; mortality; particulate matter;
D O I
10.1289/ehp.5750
中图分类号
X [环境科学、安全科学];
学科分类号
08 ; 0830 ;
摘要
In 1998 Congress mandated expanded U.S. Environmental Protection Agency (U.S. EPA) health effects research on ambient air particulate matter (PM) and a National Research Council (NRC) committee to provide research oversight. The U.S. EPA currently supports intramural and extramural PM research, including five academically based PM centers. The PM centers in their first 2.5 years have initiated research directed at critical issues identified by the NRC committee, including collaborative activities, and sponsored scientific workshops in key research areas. Through these activities, there is a better understanding of PM health effects and scientific uncertainties. Future PM centers research will focus on long-term effects associated with chronic PM exposures. This report provides a synopsis of accomplishments to date, short-term goals (during the next 2.5 years) and longer-term goals. It consists of six sections: biological mechanisms, acute effects, chronic effects, dosimetry, exposure assessment, and the specific attributes of a coordinated PM centers program.
引用
收藏
页码:1074 / 1092
页数:19
相关论文
共 81 条
[1]   Long-term inhalable particles and other air pollutants related to mortality in nonsmokers [J].
Abbey, DE ;
Nishino, N ;
McDonnell, WF ;
Burchette, RJ ;
Knutsen, SF ;
Beeson, WL ;
Yang, JX .
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 1999, 159 (02) :373-382
[2]  
ALLEN R, IN PRESS ENV SCI TEC
[3]  
[Anonymous], 1994, Ann ICRP, V24, P1
[4]   Respiratory effects of relocating to areas of differing air pollution levels [J].
Avol, EL ;
Gauderman, WJ ;
Tan, SM ;
London, SJ ;
Peters, JM .
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2001, 164 (11) :2067-2072
[5]  
Bateson TF, 2001, EPIDEMIOLOGY, V12, pS83
[6]  
BOSCIA JA, 2000, AM J RESP CRIT CARE, V161, pA239
[7]  
CHALUPA D, 2002, INIS MONOGRAPHS, P241
[8]  
CHALUPA DC, 2002, AM J RESP CRIT CARE, V165, pA829
[9]   Inhaled concentrated ambient particles are associated with hematologic and bronchoalveolar lavage changes in canines [J].
Clarke, RW ;
Coull, B ;
Reinisch, U ;
Catalano, P ;
Killingsworth, CR ;
Koutrakis, P ;
Kavouras, I ;
Murthy, GGK ;
Lawrence, J ;
Lovett, E ;
Wolfson, JM ;
Verrier, RL ;
Godleski, JJ .
ENVIRONMENTAL HEALTH PERSPECTIVES, 2000, 108 (12) :1179-1187
[10]  
CLAYTON CA, 1993, J EXPO ANAL ENV EPID, V3, P227