Practical and efficient method for amino acid derivatives containing β-quaternary center:: application toward synthesis of hepatitis C virus NS3 serine protease inhibitors

被引：26

作者：

Arasappan, Ashok ^{[1
]}

Venkatraman, Srikanth ^{[1
]}

Padilla, Angela I. ^{[1
]}

Wu, Wanli ^{[1
]}

Meng, Tao ^{[1
]}

Jin, Yan ^{[1
]}

Wong, Jesse ^{[1
]}

Prongay, Andrew ^{[1
]}

Girijavallabhan, Viyyoor ^{[1
]}

Njoroge, F. George ^{[1
]}

机构：

[1] Schering Plough Res Inst, Kenilworth, NJ 07033 USA

来源：

TETRAHEDRON LETTERS | 2007年 / 48卷 / 36期

关键词：

D O I：

10.1016/j.tetlet.2007.07.002

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A practical and efficient route toward synthesis of amino acid derivatives containing P-quaternary center has been developed using diastereo selective Strecker reaction. The method was employed for preparation of > 100 g of P-methylcyclohexyl glycine derivative, 21. Incorporation of some of the hindered amino acid derivatives at the P3 position resulted in potent HCV NS3 serine protease inhibitors. (c) 2007 Elsevier Ltd. All rights reserved.

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页码：6343 / 6347

页数：5

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