Hyaluronic acid hydrogels with IKVAV peptides for tissue repair and axonal regeneration in an injured rat brain

被引：90

作者：

Wei, Y. T. ^{[1
]}

Tian, W. M.

Yu, X.

Cui, F. Z.

Hou, S. P.

Xu, Q. Y.

Lee, In-Seop

机构：

[1] Tsing Hua Univ, Dept Mat Sci & Engn, Biomat Lab, Beijing 100084, Peoples R China

[2] Capital Univ Med Sci, Beijing Inst Neurosci, Beijing 100054, Peoples R China

[3] Yonsei Univ, Inst Phys & Appl Phys, Seoul 120749, South Korea

[4] Yonsei Univ, Atom Scale Surface Sci Res Ctr, Seoul 120749, South Korea

来源：

BIOMEDICAL MATERIALS | 2007年 / 2卷 / 03期

关键词：

D O I：

10.1088/1748-6041/2/3/S11

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 [生物医学工程];

摘要：

A biocompatible hydrogel of hyaluronic acid with the neurite-promoting peptide sequence of IKVAV was synthesized. The characterization of the hydrogel shows an open porous structure and a large surface area available for cell interaction. Its ability to promote tissue repair and axonal regeneration in the lesioned rat cerebrum is also evaluated. After implantation, the polymer hydrogel repaired the tissue defect and formed a permissive interface with the host tissue. Axonal growth occurred within the microstructure of the network. Within 6 weeks the polymer implant was invaded by host-derived tissue, glial cells, blood vessels and axons. Such a hydrogel matrix showed the properties of neuron conduction. It has the potential to repair tissue defects in the central nervous system by promoting the formation of a tissue matrix and axonal growth by replacing the lost tissue.

引用

页码：S142 / S146

页数：5

共 23 条

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Electrically mediated regeneration and guidance of adult mammalian spinal axons into polymeric channels [J].