Sequencing and comparative genomic analysis of pK29, a 269-kilobase conjugative plasmid encoding CMY-8 and CTX-M-3 β-lactamases in Klebsiella pneumoniae

被引：44

作者：

Chen, Ying-Tsong

Lauderdale, Tsai-Ling

Liao, Tsai-Lien

Shiau, Yih-Ru

Shu, Hung-Yu

Wu, Keh-Ming

Yan, Jing-Jou

Su, Ih-Jen

Tsai, Shih-Feng

机构：

[1] Natl Hlth Res Inst, Div Mol & Genom Med, Zhunan Town 350, Miaoli County, Taiwan

[2] Natl Hlth Res Inst, Div Clin Res, Zhunan 350, Miaoli, Taiwan

[3] Natl Yang Ming Univ, Genome Res Ctr, Taipei 112, Taiwan

[4] Natl Yang Ming Univ, Inst Bioinformat, Taipei 112, Taiwan

[5] Natl Cheng Kung Univ Hosp, Dept Pathol, Tainan 70428, Taiwan

[6] Natl Yang Ming Univ, Dept Life Sci, Taipei 112, Taiwan

[7] Natl Yang Ming Univ, Inst Genome Sci, Taipei 112, Taiwan

[8] Natl Tsing Hua Univ, Inst Mol Med, Hsinchu, Taiwan

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2007年 / 51卷 / 08期

关键词：

D O I：

10.1128/AAC.00167-07

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

A 269-kilobase conjugative plasmid, pK29, from a Klebsiella pneumoniae strain was sequenced. The plasmid harbors multiple antimicrobial resistance genes, including those encoding CMY-8 AmpC-type and CTX-M-3 extended-spectrum beta-lactamases in the common backbone of IncHI2 plasmids. Mechanisms for dissemination of the resistance genes are highlighted in comparative genomic analyses.

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页码：3004 / 3007

页数：4

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