Torsades de Pointes Induced by the Concomitant Use of Ivabradine and Azithromycin: An Unexpected Dangerous Interaction

被引：33

作者：

Cocco, Giuseppe ^{[1
]}

Jerie, Paul ^{[1
]}

机构：

[1] Cardiol Off, CH-4310 Rheinfelden, Switzerland

来源：

CARDIOVASCULAR TOXICOLOGY | 2015年 / 15卷 / 01期

关键词：

Pharmacodynamic toxicity; Torsades de pointes; Azithromycin; Ivabradine; Proarrhythmic effect; PHARMACOKINETIC INTERACTION; HEALTHY-VOLUNTEERS; HEART-RATE;

D O I：

10.1007/s12012-014-9274-y

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

A 68-year-old man had a cardiac syncope. He was known to have a long QT-interval and was treated with ivabradine for paroxysmal sinusal tachycardia. In the last 5 days, azithromycin had been prescribed for sinusitis. An electrocardiogram showed torsades de pointes (TdP). Azithromycin is known to prolong the QT-interval. Ivabradine does not affect the QT-interval but has a conditional risk of TdP when taken with other drugs that block its metabolic breakdown. This case presents the specific problem of a patient with long QT who received two medications, which may interact and prolong the QT.

引用

页码：104 / 106

页数：3

共 6 条

[1]

[Anonymous], 2005, GUID E14 CLIN EV QT, V70, P61134

[2]

Cargnoni A, 2006, ADV CARDIOL, V43, P31, DOI 10.1159/000095404

[3] Drugs and the QT interval - Caveat doctor [J].