Inducible nitric oxide synthase expression before and after eradication of Helicobacter pylori in different forms of gastritis

被引:26
作者
Antos, D
Enders, G
Rieder, G
Stolte, M
Bayerdörffer, E
Hatz, RA
机构
[1] Univ Munich, Klinikum Grosshadern, Dept Surg, D-81377 Munich, Germany
[2] Univ Munich, Klinikum Grosshadern, Inst Surg Res, D-81377 Munich, Germany
[3] Howard Hughes Res Inst, Ann Arbor, MI USA
[4] Kliniken Bayreuth, Dept Pathol, Bayreuth, Germany
[5] Tech Univ Hosp, Dept Med 1, Dresden, Germany
来源
FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY | 2001年 / 30卷 / 02期
关键词
intestinal metaplasia; gastritis; iNOS; Helicobacter pylori;
D O I
10.1111/j.1574-695X.2001.tb01560.x
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
An increased expression of inducible nitric oxide synthase (iNOS) has been observed in the inflamed human gastric mucosa as well as in some tumors. This observation suggests a pathobiological role of elevated NO production. The purpose of this study was to compare the immunohistochemical iNOS expression in the different kinds of gastritis before and after the eradication of Helicobacter pylori. We performed iNOS and H. pylori immunohistochemical staining and counted iNOS positive cells. We detected elevated expression of iNOS around sites infected with H. pylori. iNOS expression in chemical gastritis was strongly elevated in mucosal glands. After treatment, we found a significant difference in iNOS expression in patients with classical H. pylori-induced antrum predominant gastritis and in patients with active autoimmune gastritis. In the special case of progressed gastritis with intestinal metaplasia we found persistence of intestinal metaplasia, and we could not find a significant difference in the number of positive iNOS cells before and after treatment. The persistence of IM as a possibly precancerous lesion is probably at least in the antrum a source of continuous iNOS induction even after H. pylori eradication. (C) 2001 Federation of European Microbiological Societies. Published by Elsevier Science B.V. All rights reserved.
引用
收藏
页码:127 / 131
页数:5
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