In vitro and in vivo combinations of cefotaxime and minocycline against Aeromonas hydrophila

被引：15

作者：

Ko, WC

Lee, HC

Chuang, YC

Ten, SH

Su, CY

Wu, JJ

机构：

[1] Natl Cheng Kung Univ, Coll Med, Dept Med Technol, Tainan 70101, Taiwan

[2] Natl Cheng Kung Univ, Coll Med, Dept Med, Tainan 70101, Taiwan

[3] Natl Cheng Kung Univ, Coll Med, Dept Microbiol & Immunol, Tainan 70101, Taiwan

[4] Natl Cheng Kung Univ Hosp, Dept Internal Med, Tainan 70428, Taiwan

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2001年 / 45卷 / 04期

关键词：

D O I：

10.1128/AAC.45.4.1281-1283.2001

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The activities of cefotaxime and minocycline against Aeromonas hydrophila were investigated, Cefotaxime {4 times the MIG) plus minocycline (0.75 times the MIC) elicited an inhibitory effect for 48 h in a time-kill study, and more infected mice treated with both drugs survived (91%) than survived after treatment with cefotaxime (9%) or minocycline (44%) alone, suggesting that cefotaxime and minocycline act synergistically against A. hydrophila.

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收藏

页码：1281 / 1283

页数：3

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