Nuclear receptors orchestrate detoxification pathways

被引：18

作者：

Roy-Chowdhury, J ^{[1
]}

Locker, J ^{[1
]}

Roy-Chowdhury, N ^{[1
]}

机构：

[1] Albert Einstein Coll Med, Bronx, NY 10461 USA

来源：

DEVELOPMENTAL CELL | 2003年 / 4卷 / 05期

关键词：

D O I：

10.1016/S1534-5807(03)00131-X

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Two nuclear receptors of xenobiotic drugs, PXR and CAR, are central regulators of detoxification enzymes. New studies extend the role of these receptors to a natural detoxification process. They coordinate induction of proteins for storage, glucuronidation, and canalicular transport of bilirubin.

引用

页码：607 / 608

页数：2

共 3 条

[1] SXR, a novel steroid and xenobiotic-sensing nuclear receptor [J].