The synthesis and the electric-responsiveness of hydrogels entrapping natural polyelectrolyte

被引：61

作者：

Sutani, K

Kaetsu, I

Uchida, K

机构：

[1] Kinki Univ, Interdisciplinary Grad Sch Sci & Technol, Higashiosaka, Osaka 5778502, Japan

[2] Kinki Univ, Fac Sci & Technol, Higashiosaka, Osaka 5778502, Japan

来源：

RADIATION PHYSICS AND CHEMISTRY | 2001年 / 61卷 / 01期

关键词：

hyaluronic acid; entrapping polymerization; electro-responsive drug release; stimulus-responsive gel;

D O I：

10.1016/S0969-806X(00)00381-9

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

A mixture of vinyl monomer, a natural polyelectrolyte-hyaluronic acid-and crosslinker was polymerized and crosslinked to entrap the natural polymer into the synthetic gel. The controlled release of the model drug from the obtained gel was studied under the on-off switching of electric field. It was proved that electric-responsive drug releases were possible using hyaluronic acid entrapping gel and the electro-responsiveness was greatly affected by various factors such as degree of swelling, crosslinking density, kind and composition of vinyl monomer and crosslinkers. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：49 / 54

页数：6

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