Multiinstitutional European validation of the 2002 TNM staging system in conventional and papillary localized renal cell carcinoma

被引:59
作者
Ficarra, V
Schips, L
Guillé, F
Li, GR
De la Taille, A
Galetti, TP
Cindolo, L
Novara, G
Zigeuner, RE
Bratti, E
Tostain, J
Altieri, V
Abbou, CC
Artibani, W
Patard, JJ
机构
[1] Univ Verona, Dept Urol, Verona, Italy
[2] Graz Univ, Dept Urol, Graz, Austria
[3] Univ Rennes, Dept Urol, Rennes, France
[4] CHU St Etienne, North Hosp, Dept Urol, St Etienne, France
[5] CHU Henri Mondor, Dept Urol, Creteil, France
[6] Univ Padua, Dept Urol, Padua, Italy
[7] Univ Naples Federico II, Dept Urol, Naples, Italy
关键词
localized renal cell carcinoma; TNM staging system; nephron-sparing surgery; radial nephrectomy; partial nephrectomy; conventional renal cell carcinoma; papillary renal cell carcinoma;
D O I
10.1002/cncr.21254
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
BACKGROUND. The current study validated the 2002 edition of the TNM staging system in a multicenter, multinational European series of localized renal, cell carcinoma (RCC). METHODS. The authors analyzed the clinical data of 2217 patients who had undergone radical or partial nephrectomy for localized RCC in 7 urologic centers. RESULTS. in the current study, 1065 patients (48%) were classified as having pT1a disease, 771 (34.8%) were classified as having pT1b disease, and 381 (17.2%) were classified as having pT2 disease. Tumor histotype was conventional RCC in 1886 patients (85%), papillary in 182 (8.2%) patients, chromophobe in 64 (2.9%) patients, and unclassified in 85 (3.8%) patients. The mean follow-up time was 65.36 +/- 52.09 months. The 5 and 10-year disease- specific survival probabilities were 95.3% and 91.4% in patients with pT1a disease, 91.4% and 83.4% in patients with pT1b disease, and 81.6% and 75.2% in patients with pT2 disease (log-rank test P value = 0.0000). The disease -specific survival rates of patients with pT1a RCC were significantly higher than those recorded in patients with pT1b and pT2 RCC. Similarly, the disease -specific survival probabilities of patients with pT1b RCC were significantly better than those of patients with pT2 RCC. Analyzing the seven series individually, the 2002 TNM staging system provided appropriate stratification for only one series. The 2002 TNM staging system allowed significant stratification of the cancer-related outcomes in the subgroup of patients with conventional RCC but not in those with papillary carcinomas. CONCLUSIONS. The application of the 2002 TNM staging system in the current multicenter series enabled the authors to demonstrate optimal stratification of patients with localized RCC. Stratifying by tumor histotype, the data coming from the whole group analysis were reconfirmed for clear cell RCC only.
引用
收藏
页码:968 / 974
页数:7
相关论文
共 33 条
[1]  
Barbalias GA, 1999, J SURG ONCOL, V72, P156, DOI 10.1002/(SICI)1096-9098(199911)72:3<156::AID-JSO8>3.0.CO
[2]  
2-T
[3]   Efficacy of nephron-sparing surgery for renal cell carcinoma: Analysis based on the new 1997 tumor-node-metastasis staging system [J].
Belldegrun, A ;
Tsui, KH ;
deKernion, JB ;
Smith, RB .
JOURNAL OF CLINICAL ONCOLOGY, 1999, 17 (09) :2868-2875
[4]   Stage pT1 conventional (clear cell) renal cell carcinoma: Pathological features associated with cancer specific survival [J].
Cheville, JC ;
Blute, ML ;
Zincke, H ;
Lohse, CM ;
Weaver, AL .
JOURNAL OF UROLOGY, 2001, 166 (02) :453-456
[5]   Reassessment of the 1997 TNM classification system for renal cell carcinoma - A 5-cm T1/T2 cutoff is a better predictor of clinical outcome [J].
Elmore, JM ;
Kadesky, KT ;
Koeneman, KS ;
Sagalowsky, AI .
CANCER, 2003, 98 (11) :2329-2334
[6]   Long-term results of nephron sparing surgery for localized renal cell carcinoma: 10-year followup [J].
Fergany, AF ;
Hafez, KS ;
Novick, AC .
JOURNAL OF UROLOGY, 2000, 163 (02) :442-445
[7]   Neoplasm staging and organ-confined renal cell carcinoma: A systematic review [J].
Ficarra, V ;
Novara, G ;
Galfano, A ;
Artibani, W .
EUROPEAN UROLOGY, 2004, 46 (05) :559-564
[8]   Application of tnm, 2002 version, in localized renal cell carcinoma: Is it able to predict different cancer-specific survival probability? [J].
Ficarra, V ;
Novara, G ;
Galfano, A ;
Novella, G ;
Schiavone, D ;
Artibani, W .
UROLOGY, 2004, 63 (06) :1050-1054
[9]  
Ficarra V, 2004, UROLOGY, V63, P235, DOI 10.1016/j.urology.2003.09.081
[10]   Incidental detection beyond pathological factors as prognostic predictor of renal cell carcinoma [J].
Ficarra, V ;
Prayer-Galetti, T ;
Novella, G ;
Bratti, E ;
Maffei, N ;
Dal Bianco, M ;
Artibani, W ;
Pagano, F .
EUROPEAN UROLOGY, 2003, 43 (06) :663-669