Synthesis of β-lactones by the regioselective, cobalt and Lewis acid catalyzed carbonylation of simple and functionalized epoxides

被引：120

作者：

Lee, JT

Thomas, PJ

Alper, H

机构：

[1] Univ Ottawa, Dept Chem, Ctr Catalysis Res & Innovat, Ottawa, ON K1N 6N5, Canada

[2] Dow Chem Co USA, Corp Res & Dev, Midland, MI 48674 USA

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2001年 / 66卷 / 16期

关键词：

D O I：

10.1021/jo010295e

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The PPNCo(CO)(4) and BF3. Et2O catalyzed carbonylation of simple and functionalized epoxides in DME gives the corresponding beta -lactones regioselectively in good to high yields. The carbonylation occurred selectively at the unsubstituted C-O bond of the epoxide ring, and this reaction tolerates various functional groups such as alkenyl, halide, hydroxy, and alkyl ether.

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页码：5424 / 5426

页数：3

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