Discovery of a novel bicycloproline P2 bearing peptidyl α-ketoamide LY514962 as HCV protease inhibitor

被引：43

作者：

Yip, Y ^{[1
]}

Victor, F ^{[1
]}

Lamar, J ^{[1
]}

Johnson, R ^{[1
]}

Wang, QM ^{[1
]}

Barket, D ^{[1
]}

Glass, J ^{[1
]}

Jin, L ^{[1
]}

Liu, LF ^{[1
]}

Venable, D ^{[1
]}

Wakulchik, M ^{[1
]}

Xie, CP ^{[1
]}

Heinz, B ^{[1
]}

Villarreal, E ^{[1
]}

Colacino, J ^{[1
]}

Yumibe, N ^{[1
]}

Tebbe, M ^{[1
]}

Munroe, J ^{[1
]}

Chen, SH ^{[1
]}

机构：

[1] Eli Lilly & Co, Lilly Res Lab, Lilly Corp Ctr, Div A, Indianapolis, IN 46285 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2004年 / 14卷 / 01期

关键词：

D O I：

10.1016/j.bmcl.2003.09.074

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

We describe herein the design, syntheses and evaluation of a number of bicycloproline P2 bearing HCV protease inhibitors endowed with impressive enzyme potency, enzyme selectivity, cellular activity and favorable ADME profiles. (C) 2003 Elsevier Ltd. All rights reserved.

引用

页码：251 / 256

页数：6

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