Changing paradigms in dermatology:: Tumor necrosis factor alpha (TNF-α) blockade in psoriasis and psoriatic arthritis

被引：75

作者：

Victor, FC ^{[1
]}

Gottlieb, AB

Menter, A

机构：

[1] Univ Med & Dent New Jersey, Robert Wood Johnson Med Sch, Clin Res Ctr, New Brunswick, NJ 08903 USA

[2] Univ Texas, SW Med Sch, Dept Dermatol, Dallas, TX 75230 USA

[3] Baylor Univ, Med Ctr, Div Dermatol, Dallas, TX USA

来源：

CLINICS IN DERMATOLOGY | 2003年 / 21卷 / 05期

关键词：

D O I：

10.1016/j.clindermatol.2003.08.015

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Psoriasis is an inflammatory T cell-mediated disease characterized by epidermal hyperplasia and parakeratosis, resulting in lesional areas of thick and scaling skin. Elevated levels of proinflammatory cytokines, including TNF-alpha, are found in psoriatic lesions. TNF-alpha has many effects in producing an inflammatory response such as stimulating production of pro-inflammatory molecules (eg, IL-1, IL-6, IL-8, NF-kappaB) and adhesion molecules (eg, ICAM-1, P-selectin, E-selectin). As such, TNF-alpha is a target for immunotherapy in the treatment of psoriasis and psoriatic arthritis. The role of TNF-alpha in the pathogenesis of psoriasis is reviewed, along with clinical trials demonstrating the efficacy of new anti-TNF-alpha immunobiologics in the treatment of psoriasis and psoriatic arthritis.

引用

页码：392 / 397

页数：6

共 48 条

[1] Mast cells of psoriatic and atopic dermatitis skin are positive for TNF-α and their degranulation is associated with expression of ICAM-1 in the epidermis [J].