Cellular and molecular effects of sirtuins in health and disease

被引：110

作者：

Horio, Yoshiyuki ^{[1
]}

Hayashi, Takashi ^{[1
]}

Kuno, Atsushi ^{[1
]}

Kunimoto, Risa ^{[1
]}

机构：

[1] Sapporo Med Univ, Dept Pharmacol, Sapporo, Hokkaido 0608556, Japan

来源：

CLINICAL SCIENCE | 2011年 / 121卷 / 5-6期

关键词：

deacetylation; DNA repair; inflammation; metabolism; mitochondrion; sirtuin; stress resistance; ACTIVATED PROTEIN-KINASE; STRESS-RESPONSIVE DEACETYLASE; DEPENDENT HISTONE DEACETYLASE; PANCREATIC BETA-CELLS; FATTY-ACID OXIDATION; SACCHAROMYCES-CEREVISIAE; LIFE-SPAN; CALORIE RESTRICTION; SIRT1; DEACETYLASE; MITOCHONDRIAL-FUNCTION;

D O I：

10.1042/CS20100587

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

100103 [病原生物学]; 100218 [急诊医学];

摘要：

Sirtuins are NAD(+)-dependent protein deacetylases that are broadly conserved from bacteria to humans. Because sirtuins extend the lifespan of yeast, worms and flies, much attention has been paid to their mammalian homologues. Recent studies have revealed diverse physiological functions of sirtuins that are essentially similar to those of their yeast homologue, Sir2 (silent information regulator 2). Sirtuins are implicated in the pathology of many diseases, for which sirtuin activators such as resveratrol have great promise as potential treatments. In the present review, we describe the functions of sirtuins in cell survival, inflammation, energy metabolism, cancer and differentiation, and their impact on diseases. We also discuss the organ-specific functions of sirtuins, focusing on the brain and blood vessels.

引用

页码：191 / 203

页数：13

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