Inhibitory effect of dietary wheat bran on formation of aberrant crypt foci in rat colon induced by a single injection of 1,2-dimethylhydrazine

被引:18
作者
Ishizuka, S
Kasai, T
机构
[1] Department of Bioscience and Chemistry, Faculty of Agriculture, Hokkaido University, Sapporo, 060, Kita-9, Nishi-9, Kita-ku
关键词
aberrant crypt foci; 1,2-dimethylhydrazine; wheat bran; rat;
D O I
10.1271/bbb.60.2084
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The frequency of appearance of aberrant crypt foci (ACF) in the distal colon was significantly lower in rats fed a high fiber (20% wheat bran) diet than in those fed a fiber-free one at 4 weeks after a single injection of 1,2-dimethylhydrazine (DMH, 20 mg/kg), although crypt/ACF was high in the former relative to the latter, This result suggests that dietary wheat bran effectively serves as a regulator of ACF frequency at early stages after DMH injection.
引用
收藏
页码:2084 / 2085
页数:2
相关论文
共 17 条
[1]   EFFECT OF BETA-CAROTENE AND WHEAT BRAN FIBER ON COLONIC ABERRANT CRYPT AND TUMOR-FORMATION IN RATS EXPOSED TO AZOXYMETHANE AND HIGH DIETARY-FAT [J].
ALABASTER, O ;
TANG, ZC ;
FROST, A ;
SHIVAPURKAR, N .
CARCINOGENESIS, 1995, 16 (01) :127-132
[2]   OBSERVATION AND QUANTIFICATION OF ABERRANT CRYPTS IN THE MURINE COLON TREATED WITH A COLON CARCINOGEN - PRELIMINARY FINDINGS [J].
BIRD, RP .
CANCER LETTERS, 1987, 37 (02) :147-151
[3]   ROLE OF ABERRANT CRYPT FOCI IN UNDERSTANDING THE PATHOGENESIS OF COLON-CANCER [J].
BIRD, RP .
CANCER LETTERS, 1995, 93 (01) :55-71
[4]   FURTHER INVESTIGATION OF THE EFFECT OF CHOLIC-ACID ON THE INDUCTION, GROWTH-CHARACTERISTICS AND STABILITY OF ABERRANT CRYPT FOCI IN RAT COLON [J].
BIRD, RP .
CANCER LETTERS, 1995, 88 (02) :201-209
[5]  
BURNSTEIN MJ, 1993, SURG CLIN N AM, V73, P13
[6]  
CARTER JW, 1994, CANCER RES, V54, P4304
[7]   THE PROGRESSION OF 1,2-DIMETHYLHYDRAZINE-INDUCED COLON TUMORIGENESIS STIMULATES GROWTH AND CELL-PROLIFERATION IN THE COLON OF THE HOST MOUSE [J].
CARTER, JW ;
HARDMAN, WE ;
CAMERON, IL ;
LANCASTER, HK .
CELL PROLIFERATION, 1994, 27 (12) :741-753
[8]   SODIUM-BUTYRATE INDUCES APOPTOSIS IN HUMAN COLONIC TUMOR-CELL LINES IN A P53-INDEPENDENT PATHWAY - IMPLICATIONS FOR THE POSSIBLE ROLE OF DIETARY FIBER IN THE PREVENTION OF LARGE-BOWEL CANCER [J].
HAGUE, A ;
MANNING, AM ;
HANLON, KA ;
HUSCHTSCHA, LI ;
HART, D ;
PARASKEVA, C .
INTERNATIONAL JOURNAL OF CANCER, 1993, 55 (03) :498-505
[9]   ARTIFICIAL FIBER COMPLEXES COMPOSED OF CELLULOSE AND GUAR GUM OR PSYLLIUM MAY BE BETTER SOURCES OF SOLUBLE FIBER FOR RATS THAN COMPARABLE FIBER MIXTURES [J].
HARA, H ;
SAITO, Y ;
NAGATA, M ;
TSUJI, M ;
YAMAMOTO, K ;
KIRIYAMA, S .
JOURNAL OF NUTRITION, 1994, 124 (08) :1238-1247
[10]  
ISHIZUKA S, 1994, J NUTR SCI VITAMINOL, V40, P363