Matriderm® 1 mm versus Integra® Single Layer 1.3 mm for one-step closure of full thickness skin defects: a comparative experimental study in rats

Purpose Dermal templates, such as Matriderm (R) and Integra (R), are widely used in plastic and reconstructive surgery, often as two-step procedures. A recent development is the application of thin dermal templates covered with split thickness skin grafts in one-step procedures. In this experimental study, we compare the two thin matrices Matriderm (R) 1 mm and Integra (R) Single Layer in a one-step procedure with particular focus on neodermis formation. Methods Matriderm (R) 1 mm and Integra (R) Dermal Regeneration Template-Single Layer (1.3 mm) were compared in a rat model. In three groups of five animals each, a full thickness wound was covered with (a) Matriderm (R) 1 mm and neonatal rat epidermis, (b) Integra (R) Single Layer and neonatal rat epidermis, or, (c) neonatal rat epidermis only (control). Histological sections 2 weeks post transplantation were analyzed with regard to take of template and epidermis, neodermal thickness, collagen deposition, vascularization, and inflammatory response. Results Take of both templates was complete in all animals. The Matriderm (R)-based neodermis was thinner but showed a higher cell density than the Integra (R)-based neodermis. The other parameters were similar in both matrices. Conclusion The two templates demonstrate a comparable biological behavior early after transplantation. The only difference was found regarding neodermal thickness, probably resulting from faster degradation of Matriderm (R). These preliminary data suggest that both dermal templates appear similarly suitable for transplantation in a one-step procedure.