5-HT2C receptors are involved in the discriminative stimulus effects of citalopram in rats

被引：24

作者：

Millan, MJ ^{[1
]}

Girardon, S ^{[1
]}

Dekeyne, A ^{[1
]}

机构：

[1] Inst Rech Servier, Dept Psychopharmacol, F-78290 Paris, France

来源：

PSYCHOPHARMACOLOGY | 1999年 / 142卷 / 04期

关键词：

serotonin; discriminative stimulus; 5-HT2C; drug discrimination;

D O I：

10.1007/s002130050910

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Rats were trained on a fixed ratio 10, food-reinforced schedule to recognize a discriminative stimulus (DS) elicited by the selective serotonin (5-HT) reuptake inhibitor (SSRI), citalopram (2.5 mg/kg, IP). The preferential, high efficacy agonist at 5-HT2C receptors, Ro60-0175, dose-dependently generalized to citalopram with an ED50 of 0.3 mg/kg, IP. Further, the selective 5-HT2C receptor antagonist, SB242,084, dose-dependently (ED50=0.1 mg/kg, IP) blocked the citalopram DS. These data suggest that 5-HT2C receptors are involved in the DS properties of the SSRI, citalopram, in rats. They do not, however, exclude a potential role of other 5-HT receptor types.

引用

页码：432 / 434

页数：3

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