Imperfect interfaces

被引：32

作者：

Ysern, X

Li, HM

Mariuzza, RA

机构：

[1] Univ Maryland, Inst Biotechnol, Ctr Adv Res Biotechnol, Rockville, MD 20850 USA

[2] US FDA, Ctr Drug Evaluat & Res, Rockville, MD 20857 USA

来源：

NATURE STRUCTURAL BIOLOGY | 1998年 / 5卷 / 06期

关键词：

D O I：

10.1038/nsb0698-412

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The crystal structure of a T cell receptor bound to a self peptide-major histocompatibility complex antigen reveals poor shape complementarity in the interface between the two proteins, as well as large conformational changes in the T cell receptor combining site upon ligand binding.

引用

收藏

页码：412 / 414

页数：3

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