Degradation of the proapoptotic proteins Bik, Puma, and Bim with Bcl-2 domain 3 homology in Chlamydia trachomatis-infected cells

被引：90

作者：

Dong, F

Pirbhai, M

Xiao, YM

Zhong, YM

Wu, YM

Zhong, GM

机构：

[1] Univ Texas, Hlth Sci Ctr, Dept Microbiol & Immunol, San Antonio, TX 78229 USA

[2] Nanhua Univ, Dept Microbiol, Hunan, Peoples R China

来源：

INFECTION AND IMMUNITY | 2005年 / 73卷 / 03期

关键词：

D O I：

10.1128/IAI.73.3.1861-1864.2005

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We have previously correlated Chlamydia trachomatis antiapoptotic activity with the blockade of mitochondrial cytochrome c release and the inhibition of Bax and Bak activation. We now report that C. trachomatis infection leads to degradation of Bik, Puma, and Bim, three upstream proapoptotic BH3-only proteins of the Bcl-2 family that can transmit death signals to mitochondria by inhibiting the Bcl-2 antiapoptotic proteins and/or activating the Bcl-2 proapoptotic members, such as Bax and Bak. This observation has provided new information on the chlamydial antiapoptosis mechanisms.

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页码：1861 / 1864

页数：4

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