Synthesis of triarmed poly(ethylene oxide)-deoxycholic acid conjugate and its micellar characteristics

被引：37

作者：

Huh, KM

Lee, KY

Kwon, IC

Kim, YH

Kim, C

Jeong, SY

机构：

[1] Korea Inst Sci & Technol, Ctr Biomed Res, Seoul 130650, South Korea

[2] Inha Univ, Dept Polymer Sci & Engn, Inchon 402751, South Korea

来源：

LANGMUIR | 2000年 / 16卷 / 26期

关键词：

D O I：

10.1021/la000978+

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The triarmed polyethylene oxide-deoxycholic acid (PEO-DC) was synthesized by the introduction of a triol group to the end of the PEO chain and by a subsequent coupling reaction with deoxycholic acid. These polymeric amphiphiles formed were stable and the spherical micelles in aqueous media have a unimodal size distribution. The triarmed PEO-DC conjugate formed micelles of smaller size at a lower critical micelle concentration than those of monosubstituted ones. This was considered to result from an increase in hydrophobicity of the triarmed conjugate.

引用

页码：10566 / 10568

页数：3

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