The neuro-immune balance in neuropathic pain: Involvement of inflammatory immune cells, immune-like glial cells and cytokines

被引：476

作者：

Austin, Paul J. ^{[1
]}

Moalem-Taylor, Gila ^{[1
]}

机构：

[1] Univ New S Wales, Sch Med Sci, Sydney, NSW 2052, Australia

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2010年 / 229卷 / 1-2期

基金：

英国医学研究理事会;

关键词：

Neuropathic pain; Macrophages; Lymphocytes; Glia; Pro-/anti-inflammatory cytokines; Chemokines; TUMOR-NECROSIS-FACTOR; PERIPHERAL-NERVE INJURY; DORSAL-ROOT GANGLIA; CHRONIC CONSTRICTION INJURY; MONOCYTE CHEMOATTRACTANT PROTEIN-1; LEUKEMIA INHIBITORY FACTOR; SPINAL-CORD MICROGLIA; RAT SCIATIC-NERVE; NF-KAPPA-B; MESSENGER-RNA EXPRESSION;

D O I：

10.1016/j.jneuroim.2010.08.013

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

In a large proportion of individuals nervous system damage may lead to a debilitating chronic neuropathic pain. Such pain may now be considered a neuro-immune disorder, since recent data indicate a critical involvement of innate and adaptive immune responses following nerve injury. Activation of immune and immune-like glial cells in the injured nerve, dorsal root ganglia and spinal cord results in the release of both pro- and anti-inflammatory cytokines, as well as algesic and analgesic mediators, the balance of which determines whether pain chronicity is established. This review will critically examine the role of the immune system in modulating chronic pain in animal models of nervous system injury, and highlight the possible therapeutic opportunities to intervene in the development and maintenance of neuropathic pain. (C) 2010 Elsevier B.V. All rights reserved.

引用

页码：26 / 50

页数：25

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